Preliminary Evaluation of the Effects of Cold Atmospheric Plasma Application Rate on the Proliferation Behavior of Keratinocytes in Vitro Measured Using CK-5, CK-10, CK-14, Ki-67 and p53 Expression

Tissue tolerable plasma has been used in preclinical and more recently in clinical settings for the debridement of dead tissue and the removal of bacterial biofilms. Cold plasma therapy is an emerging field in medical sciences; it is mainly due to the beneficial effects that low temperature plasma has demonstrated: anti-inflammatory, ant tumorigenic and anti-microbial effects. 

The advantage of cold plasma therapy over conventional thermal plasma treatments, arc coagulators and desiccators, is that it allows for more precise application and therefore more controllable effects on the tissue. Additionally, cold plasma treatment showed stimulatory effects on wound healing and tissue regeneration. Experiments show that cold atmospheric plasma treatment allows for efficient, non-contact, painless, and antiseptic effects without damaging healthy tissue. As a result of the better understanding of complex plasma phenomena and the development of new plasma sources in the past few years, plasma medicine has developed into an innovative and promising field of research.