Modeling the critical issues of the
dynamics of UV-light-initiated crosslinking of corneal collagen including the
new safety criteria, crosslinking time and the efficacy. A coupled dynamic equations is numerically solved and analytic formulas are derived for three critical parameters: the safety dose (E*), the cross linking time (T*)
and the efficacy defined by the increase of corneal stiffness (S). The critical
issues of corneal crosslinking is explored by nine parameters: the three
extinction coefficients, concentration and diffusion depth of the riboflavin
solution, the UV light dose, irradiation duration, the cytotoxic energy threshold
of endothelial cells and the corneal thickness.
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