Intraductal Carcinoma of the Prostate Diagnosed by Multi-Parametric Prostate Magnetic Resonance Imaging (MRI)

Intraductal carcinoma of the prostate (IDC-P) is an aggressive form of prostate cancer (CaP) with clinical and pathological features distinguishing it from high-grade prostatic intraepithelial neoplasia (HG-PIN). IDC-P is characterized by a high volume and high-grade disease, with an aggressive behavior. We present the case of a 63-year-old male withdiagnostic MRI imaging indicative of IDC-P. To our knowledge, this is the first reported case of IDC-P identified with multi-parametric MRI.

Although, the term “intraductal carcinoma of the prostate” (IDC-P) was first used by Rhamy, McNeak and Yemoto, were the first to delineate IDC-P as a distinct biological entity with definable histological and clinical features. IDC-P is defined as aproliferation of malignant prostate adenocarcinoma cells distending orcompletely spanning the lumen of pre-existing prostatic ducts and acini, with at least focal preservation of basal cells. Watts et al. estimated the incidence of IDC-P to 2.8% in prostate biopsies.