Studies involving mechanism of
emodin, an herbal extract, has revealed its potential as anti-inflammatory,
antioxidant and anti-cancer agent. Emodin has been shown to successfully induce apoptosis, down-regulate cancer inducing genes, proving it to be a
therapeutically significant pharmacophore.
Modification of emodin and synthesis
of various derivatives have successfully increased efficacy of the molecule in
regulating various cellular pathway like MAPK signaling pathway, NF-κβsignaling pathway, ROS mediated pathways and apoptotic pathways. With the
advent of various, anti-bacterial properties of emodin may come in rescue to
combat emerging drug resistant microbial and parasitic strains. Different
emodin derivatives, including the recently reported haloemodin, which inhibits
bacterial topoisomerases, can be designed to generate future drugs against
resistant pathogens.
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