We found that such locations are
correlated to the vulnerable plaque phenotype, which is prone to rupture. Our
results demonstrate that at locations of high particle concentration, blood
particles change the shear stress distribution and magnitude.
Therefore, the
non-Newtonian blood flow assumption provides new insights in the
characterisation of plaque built up. These results are combined to in-vitro experiments that suggest the influence of blood particles in the activity of cytokines. An unbalance in pro and anti-inflammatory cytokines has been
associated to an increase in inflammation and, consequently, in the volume of
plaques forming.
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