Sequence Features and Subset Selection Technique for the Prediction of Protein Trafficking Phenomenon in Eukaryotic Non Membrane Proteins

Eukaryotic cells are organized into several membrane bound compartments. In order toperform the function; newly formed proteins get sorted and are delivered to various compartments in the non-membrane and trans-membrane pathways. 

This protein sorting process in the pathway is very complex and still not clearly understood. But the most important principle of protein trafficking is that each protein has the information on its final localization site as a part of its amino acid sequence. In 1983, Nishikawa, Kubota and 0oi had conductedinvestigations into predicting subcellular locations based on amino acidcompositions. They had reported that the amino acid compositions have the discriminating ability to classify subcellular locations.