Bioengineered Cranial Bones with Multiple Intelligent Functions

Many neurological and psychiatric disorders with predominantly cerebral cortical pathology, including most severe strokes,  traumatic  brain  injuries,  malignant  brain  tumours,  intractable  focal  epilepsies  and  dementias  such  as Alzheimer’s disease are currently difficult, if not impossible, to treat. This causes suffering in almost 100million people worldwide. We propose that bioengineered cranial bones with multiple intelligent functions, including site- specific trans meningeal drug delivery and neurotoxin drainage with EEG feedback, can provide effective treatment of these brain disorders by drug combinations that act on both synapses and genes with concomitant selective drainage of harmful extracellular molecules.