Vinyl hydrogels bearing α-aminoacid residues have been
explored as platforms for the treatment of cancer, glaucoma and mood disorder
therapies. Ionic/ionizable groups of the L-valine, L-phenylalanine and
L-histidine residues are able to modify the swelling properties of the hydrogel
on the basis of their thermodynamic characteristics.
Greater basicity constants
of functional groups improve a greater loading of the drug and a longer
sustained-release pattern. The pH and the temperature affect the swelling ofthe hydrogel and increase ‘on demand’ the drug availability. A further stimulus
based on alternating magnetic fields can be applied on hydrogels containing
embedded magnetic nanoparticles used for site-specific controlled drug
delivery.
The diffusion process for the in vitro release of the drug
(cisplatin, doxorubicin, pilocarpine, trazodone, citalopram and paroxetine)
from the drugloaded hydrogels is mainly controlled by the drug-polymerinteraction, that in the meanwhile preservs it’s bioactivity. The different
interaction strength between the drug and the polymer may be a strategy to
develop suitable capsules for long-term therapies.
No comments:
Post a Comment