Identification of Double-Step Saccades from Auditory Double-Step Stimuli is useful to guide the future stimulus designs

Voluntary Saccadic eye movements exhibit visual, auditory, and auditory-visual bisensory origins. The study that tried to examine how changing the type of sensory inputs reveals the type of saccade the oculo motor system release; whether single step or double stepped. 

The double-step auditory stimuli designed for human triggered saccadic eye movements, detecting each saccade and estimated the saccade response characteristics, namely duration and latency. Based on the latency, it is possible to determine the type of saccade generated by the subject through a clustering technique. While keeping their duration unchanged, the number of double-step saccades rises. The hindsight from this finding is useful to guide the future stimulus designs to trigger specific saccade types in humans. It demystifies the nature of dominant saccadic response as we explore the changes of sounds in any controlled environment.

Preliminary Development of a Magnetically Assisted Test Strip (MATS) Cartridge and Fluorescent DNA Aptamer-Magnetic Bead Quantum Dot Sandwich Assays for Multiplexed Food Safety Applications

Preliminary development of a simple mesofluidic multi-channel plastic cartridge with underlying external magnet to drag DNA aptamer-coated paramagnetic beads through fluids in the channels while developing a sandwich assay with quantum dot-conjugated reporter aptamers is described. 

This approach is superior to traditional lateral flow test strips in several ways including: 1) the ability to control the speed of lateral flow inthe channel versus conventional nitrocellulose analytical membranes with fixed wicking times. 2) The use of aptamers for potentially greater affinity and consistency from batch-to-batch versus comparable antibodies. 3) Superior fluorescence efficiency and intensity provided by quantum dots versus conventional fluorescent dyes and 4) the ability to multiplex based on the various colored emissions of different sized quantum dots when excited with a single ultra violet source. Development of the system from concept to prototype is described along with illustration of sensitive system performance for several food safety-related targets. The system is also clearly adaptable to rapid multiplex detection and sensitive quantitation of clinical biomarkers, drugs, environmental, veterinary or other target analytes.