Many neurological and psychiatric
disorders with predominantly cerebral cortical pathology, including most severe strokes, traumatic brain injuries, malignant brain tumors, intractable focal
epilepsies and dementias such as Alzheimer’s disease are currently difficult,
if not impossible, to treat. This causes suffering in almost 100 million people
worldwide.
We propose that bioengineered cranial bones with multiple
intelligent functions, including site specific Tran’s meningeal drug delivery
and neurotoxin drainage with EEG feedback, can provide effective treatment of these
brain disorders by drug combinations that act on both synapses and genes with
concomitant selective drainage of harmful extracellular molecules. After examining and summarizing the rationale and feasibility of this proposal, we
suggest novel methods for extending the functions of the involved components
including synergies with existing devices and we highlight relevant pre clinical
results, discussing medical prospects of this novel neuro therapeutic approach.
Finally, we discuss key engineering, scientific, clinical and ethical
challenges to introducing bio engineered cranial bones with multiple intelligent
functions to the clinic within a decade.
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