Many
neurological and psychiatric disorders with predominantly cerebral cortical
pathology, including most severe strokes, traumatic brain injuries, malignant brain tumors, intractable focal epilepsies and dementias such as Alzheimer’s disease are currently difficult, if not impossible, to treat. This causes
suffering in almost 100 million people worldwide.
We propose that bioengineered
cranial bones with multiple intelligent functions, including site specific Tran’s meningeal drug delivery and neurotoxin drainage with EEG feedback, can provide
effective treatment of these brain disorders by drug combinations that act on
both synapses and genes with concomitant selective drainage of harmful
extracellular molecules.
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