Alzheimer‘s
disease (AD) is a progressive neurodegenerative disorder, encircling the
deterioration of cognitive functions and behavioral changes, characterized by
the aggregation of amyloid β-protein (Aβ) into fibrillar amyloid plaques in
elected areas of the brain with the lipid-carrier protein apolipoprotein E
(apoE), the microtubule associated protein tau, and the presynaptic protein
α-synuclein.
High levels of fibrillary Aβ, the main constituent of senile
plaques, are deposited in the AD brain that outcome in the thrashing of
synapses, neurons and destruction of neuronal role. Aβ is derived from the amyloid precursor protein through sequential protein cleavage by as partylprotease, β-secretase and presenilin-dependent β-secretase triggering a spill
of events such as oxidative damage, neurotoxicity, and inflammation that
contributes to the progression of AD. Therefore the Aβ protein may be a target
for anti-Alzheimer drugs. Aβ proteinwas retrieved from the Protein data bankand
energy minimized and subjectedto molecular dynamic simulations using NAMD 2.9
software with CHARMM27 force field in water.
