Ischemia is a condition that happens as a result of insufficient cerebral blood flow, necessary for the brain to conduct the cerebral metabolic functions. Ischemia and reperfusion also lead to Oxidative stress and the inflammation. Reperfusion injury ignites certain pathological mechanisms, including leukocyte infiltration, destruction of blood-brain barrier, platelet activation, nitric oxide release, and apoptosis. Absence of widely applicable treatment procedures compel people to adapt to traditional or alternative medicines. Pine bark extracts that is known for rich flavonoids can act as a natural antioxidant and free radical scavenger. Aloe Vera, known for its curative and therapeutic properties for centuries possess antibacterial, antifungal and antiviral qualities can be effectively used as cure for ischemia. Topical and oral uses of Aloe vera gel are also effective in addressing this issue.
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