The mortality caused by
cardiovascular diseases is dramatically increasing. Atherosclerosis is among
the main contributors to this extremely high cardiovascular disease mortality.
Atherosclerosis is controlled by mechanical forces exerted by the flow of blood on the inner lining of arteries, the endothelium.
In order to fight this lethal
disease a realistic computational model is required that offers an accurate
understanding of the effect of blood flow on the arterial wall. In order to realistically describe complex blood flow patterns and their interaction with the arterial wall, we have developed an integrated computational technique that
takes into account both the particulate cellular composition of the blood and
the interactions between the particulate blood and the vessel wall, in
macro-circulation.
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